Lulu is married to Medizinalrat Dr. Goll. At the painter’s studio, she meets Dr. Schön and his son Alwa. When Schön and Alwa leave, the painter makes advances on Lulu. They are surprised by Dr. Goll, and he dies from the shock at what he sees.
Lulu is now married to the painter. She is visited by Schigolch, whom she has known since her childhood. Dr. Schön also visits Lulu. He wants to end his relationship with her, because he intends to marry a young woman of good standing. He explains to the painter the truth of Lulu’s past. When he learns the truth, he takes his life.
Lulu is working as a dancer at a theater. The prince takes a fascination for her, and wants to take her to Africa with him. Alwa, also present, is also fascinated by Lulu. When Lulu learns that Dr. Schön is among the spectators with his betrothed, an argument breaks out between her and Dr. Schön. Lulu forces him to break off his engagement, and dictates to him a farewell letter.
Lulu and Dr. Schön are now married. Dr. Schön observes how Lulu meets in his home with Schigolch, the athlete, and the gymnast. Countess Geschwitz is also in love with Lulu. Dr. Schön is forced to see how his own son has fallen for Lulu. He tries to force Lulu to commit suicide: instead, she shoots him.
Lulu has now been imprisoned for over a year. Alwa, Countess Geschwitz, Schigolch, and the athlete have a plan to free her, in which the countess takes her place in prison. Alwa and the athlete now await Lulu’s return. The athlete, who is engaged to Lulu and wants to have her appear as an acrobat, is horrified by her appearance, destroyed by imprisonment and illness. Lulu convinces Alwa to flee with her across the border.
Lulu, Schigolch, and Alwa have all fled to London. Lulu is now working as a prostitute. The Countess follows, bringing Lulu’s portrait with her. Lulu receives customers: the professor, a black client, who kills Alwa, and finally Jack the Ripper. When the Countess decides to begin a new life, she hears Lulu’s death cry.